Substudies
Substudy objective
Should you wish to discuss a substudy with the steering committee – send an email to trial@princess2.org
ECMO
Aims to evaluate whether intra-arrest hypothermia followed by systemic hypothermia inextracorporeal cardiopulmonary resuscitation (ECPR) patients improves neurologically intact survival compared to standard ECPR care without hypothermia. The study also aims to assess safety and feasibility of intra-arrest cooling in ECPR patients. Read more
Infection
Aims to identify and evaluate risk factors, protective factors, and preventive measures for respiratory tract and other nosocomial infections in patients after out-of-hospital cardiac arrest (OHCA), and to assess the timing of these factors and their influence on morbidity and mortality. A secondary objective is to explore whether upper airway cooling affects oropharyngeal flora and, consequently, the incidence of respiratory tract infections. Read more
Stent thrombosis
Aims to evaluate whether therapeutic hypothermia (32-34°C) increases the risk of stent thrombosis in comatose survivors of out-of-hospital cardiac arrest (OHCA) who undergo acute percutaneous coronary intervention (PCI). Read more
Temperature LAD
Aims to investigate the impact of ultrafast hypothermia on local temperatures in the infarct related artery in out-of-hospital cardiac arrest(OHCA) patients with ST-elevation myocardial infarction (STEMI), and the potential reduction of reperfusion injury, thereby limiting infarct size and enhancing cardiac recovery. Read more
Ventilation
This substudy aims to investigate whether real-time ventilation feedback via an actve EOLife device improves the restoration of spontaneous circulation (ROSC) and other clinical outcomes compared to a sham EOLife device, in patients suffering out-of-hospital cardiac arrest with shockable rhythm. Read more